The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
Por um escritor misterioso
Last updated 20 setembro 2024
Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL
The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
Defining the genetic and evolutionary architecture of alternative splicing in response to infection
From cradle to grave: RNA biology in malaria parasites - Hughes - 2010 - WIREs RNA - Wiley Online Library
Frontiers Identification of in vivo induced antigens of the malacosporean parasite Tetracapsuloides bryosalmonae (Cnidaria) using in vivo induced antigen technology
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
Trans-splicing in trypanosomes: machinery and its impact on the parasite transcriptome
Advancing Strongyloides omics data: bridging the gap with Caenorhabditis elegans
遺傳多樣性 Genetic Diversity: 最新的百科全書、新聞、評論和研究
Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion
Transcriptome analysis of alternative splicing in the pathogen life cycle in human foreskin fibroblasts infected with Trypanosoma cruzi
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
Recomendado para você
-
SWITCHBLADE Skull-T – Nomad Cigars20 setembro 2024
-
7130 Mahogany #6, Hyattsville, MD 20785, MLS# MDPG208294420 setembro 2024
-
Plants, Free Full-Text20 setembro 2024
-
Acessórios para Ferramentas20 setembro 2024
-
30.59% OFF on B2S ANITECH เครื่องบดสับอเนกประสงค์ รุ่น SCP300 สีดำ20 setembro 2024
-
29479 Woodway Dr, Wickliffe, OH 4409220 setembro 2024
-
November Issue: Smart Art by wallpaper-magazine - Issuu20 setembro 2024
-
4th of July Fireworks in Lake Mills - Enjoy Jefferson County20 setembro 2024
-
Home - Berrie Center for Performing and Visual Arts20 setembro 2024
-
SCP-7148 Land of Milk and Honey Keter [SCP Document Reading20 setembro 2024
você pode gostar
-
Baka Mitai (from Yakuza 0) for Alto Saxophone Sheet music for20 setembro 2024
-
Club Gacha Nox Mod APK for Android Download20 setembro 2024
-
GTA 3 vs. GTA VICE CITY- SIDE BY SIDE GRAPHICS AND GAMEPLAY20 setembro 2024
-
This is My Jam, Funny Jam Lover Flour Sack 100% Cotton, Kitchen20 setembro 2024
-
Go!Go!Go! - Music Crowns20 setembro 2024
-
armário guarda-comida estante art decó 1930 - Persa Antiguidades20 setembro 2024
-
Relógio Yo-kai modelo zero (zero) com medalhas em segunda mão durante 8,49 EUR em Gandía na WALLAPOP20 setembro 2024
-
The Great Cleric (Hindi Dub) The Healers' Guild - Watch on Crunchyroll20 setembro 2024
-
Teclado De Brinquedo: comprar mais barato no Submarino20 setembro 2024
-
webSeminovos Volkswagen Saveiro Cross CE 1.6 8V Branco 2013/201420 setembro 2024