A) Generation of mice with loxP-flanked target genes (flox). (1

Keratinocyte-specific knockout mice models via Cre–loxP recombination system

Gene Targeting Methods and Strategies

Cre-Lox Recombination - An Overview

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines

Flox Sequence Creation and Its Role in Genetic Manipulation

CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool: Molecular Therapy - Nucleic Acids

MGI 6.22 Introduction to Mouse Genetics

Gene-switch strategy using cre/LOX induced translational frameshift.

Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

CLICK: one-step generation of conditional knockout mice, BMC Genomics

Figure 2 from Genotyping of Cre-lox mice and detection of tissue-specific recombination by multiplex PCR.

Targeting Vector Design