Identification of and Structural Insights into Hit Compounds

The Significance of In Vitro to In Vivo Translation in Drug Discovery

Solutions for challenging targets with difficulty in hit identification - Axcelead Drug Discovery Partners, Inc.

Exploring protein hotspots by optimized fragment pharmacophores

Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries

Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors

Structural insights into SARS-CoV-2 proteins - ScienceDirect

Deep structural insights into RNA‐binding disordered protein regions - Zeke - 2022 - WIREs RNA - Wiley Online Library

Insilico Medicine leverages generative AI and

DDC, Free Full-Text

Hit Identification (Hit ID)

Cryo-EM structures of human GPR34 enable the identification of selective antagonists

Frontiers Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence - eBioMedicine

Full article: In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2

Chemistry and Pharmacology Branch (CP) National Institute on Drug Abuse (NIDA)