is GTA san Andreas Definitive edition a Multiplayer Game?

No, officially GTA San Andreas is a single-player game. there are no GTA Online features in the Definitive edition and do not have any type of multiplayer options.

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Multiplayer in GTA San Andreas, GTA Wiki

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Can we play GTA San Andreas online? Is there any way?

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GTA: Edição definitiva de San Andreas não tem co-op

If you want to play the real Definitive Edition, look up on ModDB

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Grand Theft Auto: The Trilogy – The Definitive Edition for Nintendo