Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children, International Journal of Emergency Medicine

Cerebrospinal fluid (CSF) lactate is a potential biomarker for bacterial meningitis in children. To this end, we performed a single-center retrospective cohort study of children from Sao Paulo, Brazil, with CSF pleocytosis to evaluate the ability of CSF lactate to distinguish between children with bacterial and aseptic meningitis. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. We identified 451 children of whom 40 (9%) had bacterial meningitis. Children with bacterial meningitis had a higher median CSF lactate level [9.6 mmol/l, interquartile range (IQR) 3.2-38.5 mmol/l bacterial meningitis vs. 2.0 mmol/l, IQR 1.2-2.8 mmol/l aseptic meningitis]. A CSF lactate cutoff point of 3.0 mmol/l had a sensitivity of 95% [95% confidence interval (CI) 83-99%), specificity of 94% (95% CI 90-96%) and negative predictive value of 99.3% (95% CI 97.7-99.9%) for bacterial meningitis. In combination with a validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and aseptic meningitis in children with CSF pleocytosis.

Cerebrospinal fluid findings and hypernatremia in COVID-19 patients with altered mental status, International Journal of Emergency Medicine

Clinical characteristics and molecular epidemiology of children with meningitis in Tehran, Iran: a prospective study - ScienceDirect

African Journal of Microbiology Research - etiological and predictive factors of acute meningitis in mansoura fever hospital, egypt

Interleukin-6 in cerebrospinal fluid as a biomarker of acute meningitis - Pablo García-Hernández, Belén Prieto, Eduardo Martínez-Morillo, Verónica Rodríguez, Francisco V Álvarez, 2016

PDF) Cerebrospinal fluid biomarkers in bacterial meningitis / Biomarker im Liquor cerebrospinalis bei bakterieller Meningitis

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis.

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

Frontiers Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

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PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children - ScienceDirect

The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis.

Full article: Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine deaminase in the diagnosis and outcome of acute meningitis

The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: A prospective study - Guojun Zhang, Chunjiao Yang, Xixiong Kang, Zhixian Gao