GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

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Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion - eBioMedicine

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

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CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

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Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

Recent advances and discoveries in the mechanisms and functions of CAR T cells