Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]
Por um escritor misterioso
Last updated 22 março 2025
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://dfzljdn9uc3pi.cloudfront.net/2022/14431/1/fig-1-2x.jpg)
Background Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: gag, pol, and env, each of which encodes viral proteins that can be conserved or not. ERVs have been observed in a wide range of vertebrate genomes and their functions are associated with viral silencing and gene regulation. Results In this work, we studied the evolutionary history of endogenous retroviruses associated with five human genes (INPP5B, DET1, PSMA1, USH2A, and MACROD2), which are located within intron sections. To verify the retroviral origin of the candidates, several approaches were used to detect and locate ERV elements. Both orthologous and paralogous genes were identified by Ensembl and then analyzed for ERV presence using RetroTector. A phylogenetic tree was reconstructed to identify the minimum time point of ERV acquisition. From that search, we detected ERVs throughout the primate lineage and in some other groups. Also, we identified the minimum origin of the ERVs from the parvorder Catarrhini to the Homininae subfamily. Conclusions With the data collected, and by observing the transcription factors annotated inside ERVs, we propose that these elements play a relevant role in gene expression regulation and they probably possess important features for tumorigenesis control.
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://cdnsciencepub.com/cms/10.1139/gen-2020-0104/asset/images/large/gen-2020-0104f2.jpeg)
Transcriptional enhancers: from prediction to functional
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://www.researchgate.net/publication/371353602/figure/fig1/AS:11431281166003644@1686144794382/figure-fig1_Q320.jpg)
Eduardo Tejera's research works Universidad de Las Américas
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13059-019-1757-5/MediaObjects/13059_2019_1757_Fig3_HTML.png)
Multilayered control of exon acquisition permits the emergence of
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41588-022-01132-w/MediaObjects/41588_2022_1132_Fig3_HTML.png)
Hijacking of transcriptional condensates by endogenous
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41588-022-01132-w/MediaObjects/41588_2022_1132_Fig2_HTML.png)
Hijacking of transcriptional condensates by endogenous
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fs13059-019-1757-5/MediaObjects/13059_2019_1757_Fig6_HTML.png)
Multilayered control of exon acquisition permits the emergence of
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://www.pnas.org/cms/asset/28a20ca4-cb58-4357-9de4-6a2151ce8730/keyimage.jpg)
False-positive IRESes from Hoxa9 and other genes resulting from
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://ars.els-cdn.com/content/image/1-s2.0-S2666979X2300085X-gr6.jpg)
Skipper analysis of eCLIP datasets enables sensitive detection of
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnature13804/MediaObjects/41586_2014_Article_BFnature13804_Fig1_HTML.jpg)
Primate-specific endogenous retrovirus-driven transcription
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://www.mdpi.com/ncrna/ncrna-08-00051/article_deploy/html/images/ncrna-08-00051-g001-550.jpg)
ncRNA, Free Full-Text
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnature13804/MediaObjects/41586_2014_Article_BFnature13804_Fig4_HTML.jpg)
Primate-specific endogenous retrovirus-driven transcription
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://bioone.org/ContentImages/Journals/bire/106/1/ioab173/graphic/WebImages/img-A5s_66.jpg)
Genomeactivation in equine in vitro–produced embryos†
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://royalsocietypublishing.org/cms/asset/9412f7be-af24-4374-9e15-873909f02731/rstb20120507f02.jpg)
Paleovirology of 'syncytins', retroviral env genes exapted for a
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://www.frontiersin.org/files/Articles/1128082/fgene-14-1128082-HTML-r1/image_m/fgene-14-1128082-g005.jpg)
Frontiers Integrative profiling of extrachromosomal circular DNA
![Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]](https://www.mdpi.com/ijms/ijms-23-05847/article_deploy/html/images/ijms-23-05847-g001-550.jpg)
IJMS, Free Full-Text
Recomendado para você
-
Quadra de Futebol R1022 março 2025
-
Ex-companheiro sobre R10: Nunca o vi treinar na segunda22 março 2025
-
Adriano, Robinho, R10 Veja os jogadores de álbum que não foram à Copa, Copa do Mundo22 março 2025
-
Comunicados Arquivo - CSA Equatorial22 março 2025
-
Economize tempo nas respostas para seus clientes - R10 Brasil Digital22 março 2025
-
R10 O PINTA22 março 2025
-
Canon EOS R6 (no lens included) 20.1-megapixel full-frame mirrorless camera with Wi-Fi® and Bluetooth® at Crutchfield22 março 2025
-
Ronaldinho Gaúcho tem jogo em BH no dia da inauguração da Arena MRV; entenda22 março 2025
-
Canon EOS R10 Mirrorless 4K com Lente 18-45mm STM - eMania Foto e22 março 2025
-
Câmera CANON EOS R10 + lente 18-45mm + Microfone + Grip Tripé22 março 2025
você pode gostar
-
Pinkfong Plus FIFA Women's World Cup 2023 V2 by EmbeddedRook39 on22 março 2025
-
George Nakamura faz 88 anos - Descubra Nikkei22 março 2025
-
Eradicator, Original Soundtrack of Tower Defense X22 março 2025
-
Jogo Super Mario Maker 2 Nintendo Switch no Paraguai - Atacado22 março 2025
-
Mensagem de felicidade em uma jarra de vidro saúde mental tradução felicidade22 março 2025
-
Steam Workshop::Mama Tattletail NEXTBOT [READ DESCRIPTION]22 março 2025
-
REVIEW: Bocchi the Rock Hit Surprise of Fall 202222 março 2025
-
Livro gambitos E armadilhas em Promoção na Americanas22 março 2025
-
Motosserra Homem Denji Anime Figuras De Ação Modelo Brinquedos Para Crianças Presente Montagem Chainsaw Man - Escorrega o Preço22 março 2025
-
Star*girl- a cute grunge-y cyber-y y2k look!, Gallery posted by peachiNcream22 março 2025