Vaccines, Free Full-Text
Por um escritor misterioso
Last updated 17 março 2025

The ideal vaccine against viral infections should elicit antibody responses that protect against divergent strains. Designing broadly protective vaccines against SARS-CoV-2 and other divergent viruses requires insight into the specific targets of cross-protective antibodies on the viral surface protein(s). However, unlike therapeutic monoclonal antibodies, the B-cell epitopes of vaccine-induced polyclonal antibody responses remain poorly defined. Here we show that, through the combination of neutralizing antibody functional responses with B-cell epitope mapping, it is possible to identify unique antibody targets associated with neutralization breadth. The polyclonal antibody profiles of SARS-CoV-2 index-strain-vaccinated rabbits that demonstrated a low, intermediate, or high neutralization efficiency of different SARS-CoV-2 variants of concern (VOCs) were distinctly different. Animals with an intermediate and high cross-neutralization of VOCs targeted fewer antigenic sites on the spike protein and targeted one particular epitope, subdomain 1 (SD1), situated outside the receptor binding domain (RBD). Our results indicate that a targeted functional antibody response and an additional focus on non-RBD epitopes could be effective for broad protection against different SARS-CoV-2 variants. We anticipate that the approach taken in this study can be applied to other viral vaccines for identifying future epitopes that confer cross-neutralizing antibody responses, and that our findings will inform a rational vaccine design for SARS-CoV-2.
News Flash • Get an Updated 2023-2024 COVID-19 Vaccine at No

Opposition to voluntary and mandated COVID-19 vaccination as a

Everything You Need to Know About Vaccinations

Effect of covid-19 vaccination on long covid: systematic review

Standing Orders Templates Archives

SARS-CoV-2 vaccine protection and deaths among US veterans during

Info for Parents

Revisiting COVID-19 vaccine hesitancy around the world using data

LA County COVID-19 Vaccine - LA County Department of Public Health
Recomendado para você
-
1851 map. Ancient AFRICA ANTIQUA Lea & Blanchard: Phil. 7x9.5 VG-FINE17 março 2025
-
V G Thorat Agency17 março 2025
-
Rapid Detection of SARS-CoV-2 Antigens Using High-Purity17 março 2025
-
V G Laptop World in Pushpraj Chowk,Sangli - Best Acer-Computer17 março 2025
-
Exploration of Mars - Wikipedia17 março 2025
-
ID-Pal – Apps no Google Play17 março 2025
-
Ultimate Computers in Palus,Sangli - Best Second Hand Computer17 março 2025
-
Synthesis of Oxazolidin‐2‐ones by Oxidative Coupling of17 março 2025
-
Clinical and Prognostic Relevance of Cardiac Wasting in Patients17 março 2025
-
PDF) The Role of Large Arthropods in the Development of17 março 2025
você pode gostar
-
Clube Águia + - Apps on Google Play17 março 2025
-
Anime DVD Initial D Season 1-6 + 3 Extra Stage + 3 Battle Stage + 3 Legend + OST17 março 2025
-
Kizi Kart Racing 🔥 Jogue online17 março 2025
-
How to make AI generated Roblox GFX with no work!17 março 2025
-
WARFRAME - Embody the System's most dangerous flora as Khora Urushu on PC. 🌹🐱17 março 2025
-
Friday Night Funkin' Logic - Playable Player [Friday Night Funkin17 março 2025
-
A unique metal sonic design17 março 2025
-
Fire Force (tome 1) - (Atsushi Ohkubo) - Shonen [CANAL-BD]17 março 2025
-
Seriously do they even read the manga? Buggy's supposed to be intimidating in the East Blue saga : r/OnePiece17 março 2025
-
Mahou Shoujo Lyrical Nanoha (Magical Girl Lyrical Nanoha) Mobile17 março 2025