Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

Temozolomide (NSC 362856), DNA Alkylator

Table 1 from Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines - Tresch - 2021 - Veterinary Medicine and Science - Wiley Online Library

Molecules, Free Full-Text

Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?

Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856), DNA Alkylator

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules

Temozolomide resistance in glioblastoma multiforme - ScienceDirect

Selleck Chemical LLC Temozolomide 100mg 85622-93-1 CCRG81045, NSC 362856,TMZ

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Temozolomide Supplier, CAS 85622-93-1