Sire, Gears of War Wiki

quot;Dalyell had always been very cagey about their existence and origin. Prescott had been kept out of the loop: it had suited him not to know about mutated humans, poisoned humans, but it was a gap he now needed to fill. All he could do when he took office was keep the New Hope facility quarantined and hope he never had to open the lid." —Chairman Richard Prescott's knowledge of the Sires. Sires were human chimeras mutated by Imulsion-poisoning and genetic experimentation as children, and were for

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Sire, Gears of War Wiki