Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity - Syrett - 2019 - Journal of Leukocyte Biology - Wiley Online Library

Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells - ScienceDirect

PDF) Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities

Escape genes are marked by unique mCG and mCH patterns. (A)

A schematic diagram of contribution of escape genes to the female bias

Frontiers X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis”

A stain upon the silence: genes escaping X inactivation: Trends in Genetics

IJMS, Free Full-Text

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing, Epigenetics & Chromatin

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

Gene regulation in time and space during X-chromosome inactivation