Neurons-on-a-Chip for Drug Development & Neurotoxicity

High throughput microfluidic devices to accelerate drug development in neuroscience.

Frontiers Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges - Geerts - 2020 - CPT: Pharmacometrics & Systems Pharmacology - Wiley Online Library

Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application - Wang - Small - Wiley Online Library

Organ-on-a-Chip Neurotoxicity Models

Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures

Comparison of two neurotoxicity assays on typical illicit drugs. (A)

Frontiers Motor neuron-derived induced pluripotent stem cells as a drug screening platform for amyotrophic lateral sclerosis

Organs-on-Chips: Expand the Boundaries of In Vitro Testing

Organs-on-a-Chip in Preclinical Studies

Frontiers Potential of Microfluidics and Lab-on-Chip Platforms to Improve Understanding of “prion-like” Protein Assembly and Behavior

Multiplexed cell based assay of neuronal structure function for neurotoxicity and disease modeling

Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration - Abigail L Walker, Syed Z Imam, Ruth A Roberts, 2018

Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration

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