Membrane Composition and Raf[CRD]-Membrane Attachment Are

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Configurations of C-Raf RBD-CRD (C-Raf) in solution. (a) Starting

Ras isoform-specific expression, chromatin accessibility, and signaling

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

a) Schematic orientation states of RAS, which have different exposures

Membrane curvature sensing of the lipid-anchored K-Ras small GTPase

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling - ScienceDirect

Cryo-EM structure of a RAS/RAF recruitment complex

Tug of war between K-Ras4B and C-Raf CRD membrane interactions. (a)

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling - ScienceDirect

Raf associates with cholesterol and lipid rafts. A, association of

Distance of salt bridges between D154 and R161 for the K-Ras4B dimer on

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Ras membrane orientation and nanodomain localization generate isoform diversity