Membrane Composition and Raf[CRD]-Membrane Attachment Are
Por um escritor misterioso
Last updated 28 março 2025
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://pubs.acs.org/cms/10.1021/acs.jpcb.1c01184/asset/images/medium/jp1c01184_0008.gif)
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.mdpi.com/biomolecules/biomolecules-10-01522/article_deploy/html/images/biomolecules-10-01522-g004.png)
Biomolecules, Free Full-Text
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.researchgate.net/publication/323198632/figure/fig1/AS:594291437092864@1518701528347/Configurations-of-C-Raf-RBD-CRD-C-Raf-in-solution-a-Starting-structure-b.png)
Configurations of C-Raf RBD-CRD (C-Raf) in solution. (a) Starting
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs12551-021-00817-6/MediaObjects/12551_2021_817_Fig4_HTML.png)
Ras isoform-specific expression, chromatin accessibility, and signaling
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.pnas.org/cms/10.1073/pnas.2006504117/asset/a4a3f2da-af08-407a-a31f-00edc5bced89/assets/images/large/pnas.2006504117fig01.jpg)
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
a) Schematic orientation states of RAS, which have different exposures
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.life-science-alliance.org/content/lsa/2/4/e201900343/F1.large.jpg)
Membrane curvature sensing of the lipid-anchored K-Ras small GTPase
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://ars.els-cdn.com/content/image/1-s2.0-S096921261830011X-gr1.jpg)
Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling - ScienceDirect
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41467-023-40299-6/MediaObjects/41467_2023_40299_Fig2_HTML.png)
Cryo-EM structure of a RAS/RAF recruitment complex
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.researchgate.net/publication/323198632/figure/fig2/AS:594291437088768@1518701528386/Membrane-binding-dynamics-of-the-C-Raf-K-Ras4B-complex-a-b-Time-evolution-of-the_Q320.jpg)
Tug of war between K-Ras4B and C-Raf CRD membrane interactions. (a)
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.pnas.org/cms/10.1073/pnas.2006504117/asset/d4908c12-3dbc-436c-8f78-b50cb4b62da3/assets/images/large/pnas.2006504117fig03.jpg)
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://ars.els-cdn.com/content/image/1-s2.0-S096921261830011X-gr8.jpg)
Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling - ScienceDirect
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.researchgate.net/publication/11414441/figure/fig5/AS:394559096934406@1471081627342/Raf-associates-with-cholesterol-and-lipid-rafts-A-association-of-GST-C-Raf-10-pmol.png)
Raf associates with cholesterol and lipid rafts. A, association of
Distance of salt bridges between D154 and R161 for the K-Ras4B dimer on
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.pnas.org/cms/10.1073/pnas.2006504117/asset/f8eb8af7-38e3-4bfa-98e8-2262899117b2/assets/images/large/pnas.2006504117fig02.jpg)
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
![Membrane Composition and Raf[CRD]-Membrane Attachment Are](https://www.pnas.org/cms/10.1073/pnas.0903907107/asset/9ba64935-3399-4148-87c6-364a3f04c989/assets/graphic/pnas.0903907107fig06.jpeg)
Ras membrane orientation and nanodomain localization generate isoform diversity
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