Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 31 março 2025

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

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Dissociation of functional and structural plasticity of dendritic spines

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

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Fragile X Syndrome - ScienceDirect

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