Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 22 março 2025

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

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Frontiers Local Translation Across Neural Development: A Focus

Biomolecules, Free Full-Text

Dissociation of functional and structural plasticity of dendritic spines

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

Frontiers Homeostatic Roles of the Proteostasis Network in Dendrites

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Fragile X Syndrome - ScienceDirect

Depletion of the Fragile X Mental Retardation Protein in Embryonic
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