JoF, Free Full-Text
Por um escritor misterioso
Last updated 19 setembro 2024
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are believed to be infected. In Brazil, it is ranked as the tenth most common cause of death among chronic infectious diseases. Hence, vaccines are in development to combat this insidious pathogen. It is likely that effective vaccines will need to elicit strong T cell-mediated immune responses composed of IFNγ secreting CD4+ helper and CD8+ cytolytic T lymphocytes. To induce such responses, it would be valuable to harness the dendritic cell (DC) system of antigen-presenting cells. To assess the potential of targeting P10, which is a peptide derived from gp43 secreted by the fungus, directly to DCs, we cloned the P10 sequence in fusion with a monoclonal antibody to the DEC205 receptor, an endocytic receptor that is abundant on DCs in lymphoid tissues. We verified that a single injection of the αDEC/P10 antibody caused DCs to produce a large amount of IFNγ. Administration of the chimeric antibody to mice resulted in a significant increase in the levels of IFN-γ and IL-4 in lung tissue relative to control animals. In therapeutic assays, mice pretreated with αDEC/P10 had significantly lower fungal burdens compared to control infected mice, and the architecture of the pulmonary tissues of αDEC/P10 chimera-treated mice was largely normal. Altogether, the results obtained so far indicate that targeting P10 through a αDEC/P10 chimeric antibody in the presence of polyriboinosinic: polyribocytidylic acid is a promising strategy in vaccination and therapeutic protocols to combat PCM.
Guided paragraph writing : a first course in English composition with structural practice : Jupp, T. C. (Thomas Cyprian) : Free Download, Borrow, and Streaming : Internet Archive
Antibiotics, Free Full-Text
Gratis Open Access Publishers
Scolary — JURN
Full-Text Psychology Journals and Articles
Ogi Cardiff
Section D Free E-journals Access Directory of Open Access Journals BioMed Central PubMed Central HighWire Press PubMed search options. - ppt download
EBSCO Developer PublicationIQ Browse Database Overview
Nathan Fernance - Sports Physiotherapist - ATUNE Health Centres
Recomendado para você
-
Revista Robótica 113 by Revista Robotica - Issuu19 setembro 2024
-
AEC Group, LLC19 setembro 2024
-
Outra premiação, mais um destaque. AeC conquista 4 prêmios no SMART Customer 2020. - AeC19 setembro 2024
-
Marcia Persi19 setembro 2024
-
IJMS, Free Full-Text19 setembro 2024
-
ClickAR - Apps on Google Play19 setembro 2024
-
Cells, Free Full-Text19 setembro 2024
-
Full article: COVID-19 pandemic sheds light on the importance of food safety practices: risks, global recommendations, and perspectives19 setembro 2024
-
Lagos: AEC já têm data para iniciar nas escolas lacobrigenses19 setembro 2024
-
SAM L10/L11 ARM® Cortex®-M23 MCUs - Microchip Technology19 setembro 2024
você pode gostar
-
Dragon Age Origins [Elf Mage] with Commentary [Part 52]: Mommy Issues19 setembro 2024
-
MINECRAFT DE GRAÇA NA PLAYSTORE!19 setembro 2024
-
Call Of Duty: WWII Game Review19 setembro 2024
-
CD Forró Sacode As 20+19 setembro 2024
-
Show Your Home Made Shop Press19 setembro 2024
-
Kyoukai no Kanata Movie 1: I'll Be Here-Kako-hen – KSensei19 setembro 2024
-
Chaos Control Freaks, Sonic X Wikia19 setembro 2024
-
Services Seriously Smart Tech19 setembro 2024
-
Agora sim! God of War Ragnarök ganha data de lançamento oficial!19 setembro 2024
-
World Trigger (Blu-ray), Sentai, Anime & Animation19 setembro 2024