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Doctor Nitrus Brio (also known as N. Brio, or simply Brio) is a major antagonist in the Crash Bandicoot franchise. He is a mentally unstable scientist, who served as a former assistant for Dr. Neo Cortex's global domination, brewing potions and transforming animals into mutants. Brio's loyalty has fluctuated throughout the series, whether he's working on his own accords, with Doctor Nefarious Tropy, or even returning to Cortex's side. As of Cortex Strikes Back, he is replaced by Dr. N. Gin. Like

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