Cells, Free Full-Text
Por um escritor misterioso
Last updated 31 março 2025

Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.

Cell-free gene expression: an expanded repertoire of applications

Rapid cell-free forward engineering of novel genetic ring oscillators

Remote immune processes revealed by immune-derived circulating cell-free DNA
Mol Imaging Radionucl Ther on X: The Role of a Bone SPECT/CT Scan in the Follow-up of a Solitary Bone Lesion in a Patient with Langerhans' Cell Histiocytosis You can see the

Cells, Free Full-Text

Towards reproducible cell-free systems

Improving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles

Nt Novo Cella Get File - Colaboratory

10M Beep Test Download - Colaboratory

Cell-free expression and synthesis of viruses and bacteriophages: applications to medicine and nanotechnology - ScienceDirect

An integrated in vivo/in vitro framework to enhance cell-free biosynthesis with metabolically rewired yeast extracts

Frontiers Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation
Cell-Free Gene Expression: Methods and Protocols

Cell-free methods to produce structurally intact mammalian membrane proteins

Textile-embedded cell-free biosensors
Recomendado para você
-
6 problemas que a Robbyson ajuda a resolver com tecnologia de31 março 2025
-
Robbyson Corporate Mobile - Aplikacije na Google Playu31 março 2025
-
Premium Photo Asian boy dressed in dark blue with a light blue31 março 2025
-
Premium Photo Asian boy dressed in dark blue with a light blue31 março 2025
-
Asesor en Línea - Apps on Google Play31 março 2025
-
Robbyson Corporate Mobile APK (Android App) - Free Download31 março 2025
-
Francisco Aquino on Behance31 março 2025
-
robbyson.com31 março 2025
-
New Colorado College Arena Links Campus, Downtown31 março 2025
-
Lawrence Klein no LinkedIn: #robbyson #conarec31 março 2025
você pode gostar
-
Red Dead Redemption 2 - PC [Online Game Code]31 março 2025
-
id de roupas do brookhaven masculino conjunto|TikTok Search31 março 2025
-
Pure Insanity - The Outlast Trials Thumbnail by ZPuppy.Art -- Fur31 março 2025
-
º•»SUIKA SENSEI (🍉COMISSIONS OPEN🍉)«•º on X: 🍕🐻a beautiful drawing of GOLDEN FREDDY from FIVE NIGHTS AT FREDDY'S.🐻🍕 🍉I have given it this golden touch that makes it look super nice, I hope31 março 2025
-
That's the Spirit - Wikipedia31 março 2025
-
Uma nova pista de corrida com obstáculos. 4 carros coloridos31 março 2025
-
Demon Slayer Roblox ID - Roblox music codes31 março 2025
-
American Express31 março 2025
-
Redo of Healer Season 2 Release Date: Here's an Exact Situation! (December 2023) - Anime Ukiyo31 março 2025
-
Jonathan Majors Returns In The Trailer For 'Loki' Season 231 março 2025