Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Por um escritor misterioso
Last updated 31 março 2025

Sporadic amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects particularly motoneurons. Several pieces of evidence suggested the involvement of autoimmune mechanisms mediated by antibodies in ALS. However, the significance of those antibodies in the disease and the underlying mechanisms are unknown. Here we showed that IgG purified from a group of sporadic ALS patients, but not familial ALS patients, specifically interact with the presynaptic membrane of motoneurons through an antigen–antibody interaction and modulated synaptic transmission. Immunoreactivity against nerve terminals showed strong correlation with synaptic modulation ability. In addition, several controls have ruled out the possibility for this synaptic modulation to be mediated through proteases or nonspecific effects. Effective IgG potentiated both spontaneous and asynchronous transmitter release. Application of pharmacological inhibitors suggested that activation of this increased release required a nonconstitutive Ca2+ influx through N-type (Cav2.2) channels and phospholipase C activity and that activation of IP3 and ryanodine receptors were necessary to both activate and sustain the increased release. Consistent with the notion that ALS is heterogeneous disorder, our results reveal that, in ∼50% of ALS patients, motor nerve terminals constitutes a target for autoimmune response.

Glia cells in amyotrophic lateral sclerosis: New clues to

Increased Synaptic ATP Release and CD73-Mediated Formation of

Calcium in the pathomechanism of amyotrophic lateral sclerosis

Astrocytes as master modulators of neural networks: Synaptic

Motoneuron Death Triggered by a Specific Pathway Downstream of Fas

IJMS, Free Full-Text

The Neuroinflammation in the Physiopathology of Amyotrophic

Transcranial magnetic stimulation and amyotrophic lateral
Increased Synaptic ATP Release and CD73-Mediated Formation of

Calcium signaling in neurodegeneration

Activity-dependent endoplasmic reticulum Ca2+ uptake depends on

IJMS, Free Full-Text
Recomendado para você
-
Abnormal Exit31 março 2025
-
Igg Games Reviews, Read Customer Service Reviews of igg-games.com31 março 2025
-
Effect of the multilayer structure on the immunoassay. Antigen-antibody31 março 2025
-
4win31 março 2025
-
Dg Stock Vector Illustration and Royalty Free Dg Clipart31 março 2025
-
Frontiers EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle31 março 2025
-
Immobilization of the IgG and Prostate Specific Antigen (PSA) on SU-831 março 2025
-
100pcs Finishing Nails Hand-Drive Hardware Carbon Steel Nail 25mm 1-inches : Industrial & Scientific31 março 2025
-
Standardization of a Cytometric Bead Assay Based on Egg-Yolk Antibodies31 março 2025
-
Stimulation of Unprimed Macrophages with Immune Complexes Triggers a Low Output of Nitric Oxide by Calcium-dependent Neuronal Nitric-oxide Synthase - ScienceDirect31 março 2025
você pode gostar
-
Destiny 2 Lightfall: Neomuna Region Chest locations - Polygon31 março 2025
-
Call of Duty: Modern Warfare 2 • Xbox 360 – Mikes Game Shop31 março 2025
-
Persona 3 in the art style of Persona 5 (OC) : r/PERSoNA31 março 2025
-
Wild Hearts: versão de testes está disponível na PS Store31 março 2025
-
A FAZENDA 14 AO VIVO - GRANDE FINAL playplus ao vivo - A FAZENDA 2022 record ao vivo31 março 2025
-
Em confronto direto na parte de cima da tabela, Atlético-MG recebe31 março 2025
-
HighRoller Vegas31 março 2025
-
Console Sony Playstation5 Midia Física Marvel's Spider-man 231 março 2025
-
Solved 5. Sisters Andrea and Alexandra Botez are chess31 março 2025
-
Chicken Pintadinha design with Chick Piu Piu full video 201531 março 2025